Moringa belongs to exotic Chinese medicine resources, from the perspective of traditional Chinese medicine, Moringa leaves are cold, sweet, bitter, to the liver, spleen (or stomach) meridian, can be used to treat spleen deficiency phlegm and wet type of diabetes. With the help of laboratory methods, it is possible to more objectively assess and evaluate the actual efficacy of MOL in lowering blood glucose and the mechanism of influence # MOL in the macronutrient and trace element content is very rich, the use of particle-induced g-ray emission technology analysis found that there is a different content of MOL Cl, K, Ca, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Br, Sr, and other elements, which is to the C1, K and Ca content, the content of C1, K and Ca. C1, K and Ca have the highest content, followed by Mn, and Zn and Cr are also rich in content. It was found that trace elements can help to improve glucose and lipid metabolism in diabetic mice, which is closely related to the treatment of diabetes mellitus.

    MOL proteins and peptides have hypoglycemic effects. paula et al. isolated a MO protein with insulin-like antigenic epitope, which may be related to hypoglycemia. paulo et al. isolated a MOL protein with agglutination activity and cross-reactivity with anti-insulin antibody, which can increase CAT activity and improve the oxidative stress state of diabetic mice. aderinola et al. isolated a MO peptide with the ability to increase CAT activity and improve the state of diabetes. A MO polypeptide was isolated, which has scavenging free radicals, d radicals, iron ion reducing ability and metal chelating ability, and also inhibits angiotensin-converting enzyme, and the inhibitory effect is gradually enhanced with increasing molecular weight.

    MOL polysaccharides, flavonoids, polyphenols and other functional active ingredients have hypoglycemic effect#CHEN et al. isolated three kinds of polysaccharides with different molecular weights (9.68#103, 6.29$103, 4.86$103 kDa), which are composed of xylose, mannose, glucose, galactose, and arabinose, and among them, the inhibitory effects of small molecular weight polysaccharides on -amylase and -glucose W-enzyme are stronger than those of large molecular weight polysaccharides. Large molecular weight polysaccharides #Isosakic acid W as the main component of MOL flavonoids, JILILEY.com found that isosakic acid W can up-regulate the expression of PI3K and Akt, and activate the PI3K/Akt pathway, which suggests that MOL flavonoids and isosakic acid Xie can protect the pancreas and the liver by inhibiting apoptosis and promoting cell proliferation #JIMOH rick found that MOL polyphenols have an inhibitory effect on -amylase and -glucose W enzyme, and chelating effect on Cu2_ and Fe2' metal ions, suggesting that MOL polyphenol substances have an important role in the hypoglycemic effect.

    Other functional active ingredients such as larch resin alcohol and isothio;acid ester in MOL have hypoglycemic potential value. Chunxia Chu et al. isolated larch resin alcohol and 3-(!),4-di-W-based polyphenols from the phloem of Moringa officinalis. ,4-di-W-based-3-methoxyphenylmethyl)-4-(W-based-3-methoxyphenylmethyl)tetrahydro-enantiomers, which were shown to have an inhibitory effect on -glucose f-enzyme.WATERMAN et al. He found that 5% moringa concentrate (containing moringa isothi;ate esters) could promote fat accumulation, improve glucose tolerance and insulin signaling, and at the same time be able to reduce plasma insulin in C57BL/6L mice, leptin, resistin, and hepatic glucose 6-phosphatase (G-6-P) protein expression [4,57] OZAINAB et al. net screened in silico method (In-silico method % from MOL) for onychoguanin, 2-phenylchromanin (anthocyanin), hemlock tannins, glutathione (sugar f) and ! -phenolic flutes and other five phytochemicals, which can bind effectively within the active binding pocket of the target protein, suggesting that these five compounds have antidiabetic value. Sand scale et al. (iv) found that MOL can be symptomatic for the treatment of tumors, diabetes and digestive diseases and other related diseases through text mining and molecular docking technology screening, and the molecular docking results showed that 12 potential targets of action and 25 active ingredients are related to MOL for the treatment of the above mentioned diseases, and that the regulatory mechanism may be related to the G-protein-coupled receptor and the regulation of inflammatory response.